Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense

The human fungal pathogens Candida albicans and Histoplasma capsulatum have been reported to protect against the oxidative burst of host innate immune cells using a family of extracellular proteins with similarity to Cu/Zn superoxide dismutase 1 (SOD1). We report here that these molecules are widesp...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. USA 2014-04, Vol.111 (16), p.5866-5871
Hauptverfasser:	Gleason, Julie E., Galaleldeen, Ahmad, Peterson, Ryan L., Taylor, Alexander B., Holloway, Stephen P., Waninger-Saroni, Jessica, Cormack, Brendan P., Cabelli, Diane E., Hart, P. John, Culotta, Valeria Cizewski
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Amino Acid Sequence Binding sites Biological Sciences Candida albicans Candida albicans - enzymology Candida albicans - immunology Catalysis catalytic activity Copper Copper - metabolism Crystals Defense mechanisms Disulfides Electrostatics enzyme activity Enzymes Extracellular Space - metabolism fungal proteins Fungal Proteins - chemistry Fungal Proteins - metabolism Fungi gene induction Histoplasma capsulatum Humans Immunity (Disease) Kinetics Models, Molecular Molecular Sequence Data Oxidative stress Pathogens Proteins Pulse Radiolysis Sequence Analysis, Protein solvents Structural Homology, Protein superoxide dismutase Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism Superoxides Zinc
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