Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype

Polycystic ovary syndrome (PCOS), characterized by increased ovarian androgen biosynthesis, anovulation, and infertility, affects 5-7% of reproductive-age women. Genome-wide association studies identified PCOS candidate loci that were replicated in subsequent reports, including DENND1A, which encode...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-04, Vol.111 (15), p.5455-5455
Hauptverfasser:	McAllister, Jan M., Modi, Bhavi, Miller, Bruce A., Biegler, Jessica, Bruggeman, Richard, Legro, Richard S., Strauss, Jerome F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Androgens - biosynthesis animal ovaries anovulation Biological Sciences Biosynthesis Cholesterol Side-Chain Cleavage Enzyme - metabolism cytoplasm Death Domain Receptor Signaling Adaptor Proteins - metabolism Enzyme-Linked Immunosorbent Assay Female Gene expression gene overexpression genes Genome-Wide Association Study Genomics Guanine Nucleotide Exchange Factors Humans Hyperandrogenism - genetics Hyperandrogenism - metabolism immunoglobulin G Immunoglobulin G - immunology Immunohistochemistry loci messenger RNA Pathogenesis phenotype PNAS Plus PNAS Plus: Significance Statements Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Real-Time Polymerase Chain Reaction receptors RNA-protein interactions Steroid 17-alpha-Hydroxylase - metabolism Theca Cells - metabolism transcription (genetics) urine women Womens health
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