Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer
We reported earlier the delivery of antiangiogenic single chain antibodies by using oncolytic vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by inserti...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (9), p.3316-3320 |
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| creator | Stritzker, Jochen Kirscher, Lorenz Scadeng, Miriam Deliolanis, Nikolaos C. Morscher, Stefan Symvoulidis, Panagiotis Schaefer, Karin Zhang, Qian Buckel, Lisa Hess, Michael Donat, Ulrike Bradley, William G. Ntziachristos, Vasilis Szalay, Aladar A. |
| description | We reported earlier the delivery of antiangiogenic single chain antibodies by using oncolytic vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain. We found that produced melanin is an excellent reporter for optical imaging without addition of substrate. Melanin production also facilitated deep tissue optoacoustic imaging as well as MRI. In addition, melanin was shown to be a suitable target for laser-induced thermotherapy and enhanced oncolytic viral therapy. In conclusion, melanin as a mediator for thermotherapy and reporter for different imaging modalities may soon become a versatile alternative to replace fluorescent proteins also in other biological systems. After ongoing extensive preclinical studies, melanin overproducing oncolytic virus strains might be used in clinical trials in patients with cancer. |
| doi_str_mv | 10.1073/pnas.1216916110 |
| format | Article |
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Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain. We found that produced melanin is an excellent reporter for optical imaging without addition of substrate. Melanin production also facilitated deep tissue optoacoustic imaging as well as MRI. In addition, melanin was shown to be a suitable target for laser-induced thermotherapy and enhanced oncolytic viral therapy. In conclusion, melanin as a mediator for thermotherapy and reporter for different imaging modalities may soon become a versatile alternative to replace fluorescent proteins also in other biological systems. After ongoing extensive preclinical studies, melanin overproducing oncolytic virus strains might be used in clinical trials in patients with cancer.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1216916110</identifier><identifier>PMID: 23401518</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; antibodies ; Biological Sciences ; Cancer ; clinical trials ; fluorescent proteins ; Genes ; HeLa Cells ; Humans ; Hyperthermia, Induced - methods ; image analysis ; Imaging ; Induced hyperthermia ; Infections ; Infrared Rays ; Lasers ; Lymph nodes ; Magnetic Resonance Imaging ; Melanin ; Melanins - biosynthesis ; Mice ; Neoplasm Metastasis ; neoplasms ; Neoplasms - metabolism ; Neoplasms - pathology ; Neoplasms - therapy ; patients ; Photoacoustic Techniques - methods ; Proteins ; Substrates ; thermotherapy ; Tissues ; Tumors ; Vaccinia virus ; Vaccinia virus - metabolism ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (9), p.3316-3320</ispartof><rights>copyright © 1993-2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Feb 26, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-be89072bbf15ebaadf339a0fd2390c8fcd121f2d90504e5ab3f5e8e36cbb7c2a3</citedby><cites>FETCH-LOGICAL-c523t-be89072bbf15ebaadf339a0fd2390c8fcd121f2d90504e5ab3f5e8e36cbb7c2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/110/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42583595$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42583595$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23401518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stritzker, Jochen</creatorcontrib><creatorcontrib>Kirscher, Lorenz</creatorcontrib><creatorcontrib>Scadeng, Miriam</creatorcontrib><creatorcontrib>Deliolanis, Nikolaos C.</creatorcontrib><creatorcontrib>Morscher, Stefan</creatorcontrib><creatorcontrib>Symvoulidis, Panagiotis</creatorcontrib><creatorcontrib>Schaefer, Karin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Buckel, Lisa</creatorcontrib><creatorcontrib>Hess, Michael</creatorcontrib><creatorcontrib>Donat, Ulrike</creatorcontrib><creatorcontrib>Bradley, William G.</creatorcontrib><creatorcontrib>Ntziachristos, Vasilis</creatorcontrib><creatorcontrib>Szalay, Aladar A.</creatorcontrib><title>Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We reported earlier the delivery of antiangiogenic single chain antibodies by using oncolytic vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain. We found that produced melanin is an excellent reporter for optical imaging without addition of substrate. Melanin production also facilitated deep tissue optoacoustic imaging as well as MRI. In addition, melanin was shown to be a suitable target for laser-induced thermotherapy and enhanced oncolytic viral therapy. In conclusion, melanin as a mediator for thermotherapy and reporter for different imaging modalities may soon become a versatile alternative to replace fluorescent proteins also in other biological systems. After ongoing extensive preclinical studies, melanin overproducing oncolytic virus strains might be used in clinical trials in patients with cancer.</description><subject>Animals</subject><subject>antibodies</subject><subject>Biological Sciences</subject><subject>Cancer</subject><subject>clinical trials</subject><subject>fluorescent proteins</subject><subject>Genes</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>image analysis</subject><subject>Imaging</subject><subject>Induced hyperthermia</subject><subject>Infections</subject><subject>Infrared Rays</subject><subject>Lasers</subject><subject>Lymph nodes</subject><subject>Magnetic Resonance Imaging</subject><subject>Melanin</subject><subject>Melanins - biosynthesis</subject><subject>Mice</subject><subject>Neoplasm Metastasis</subject><subject>neoplasms</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>patients</subject><subject>Photoacoustic Techniques - methods</subject><subject>Proteins</subject><subject>Substrates</subject><subject>thermotherapy</subject><subject>Tissues</subject><subject>Tumors</subject><subject>Vaccinia virus</subject><subject>Vaccinia virus - metabolism</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEotvCmRNgqRcuacd2nNgXJFTxJRUhAeVqTRxn61XWTu2kqGf-OE63LIULF_vgZx7NvJ6ieEbhhELDT0eP6YQyWitaUwoPihUFRcu6UvCwWAGwppQVqw6Kw5Q2AKCEhMfFAeMVUEHlqvj5HY1x3iG5dnFO5dZ2Difbka0d0DtPxhi62UwueILDEH4k8ukLQd-RME4BTZjT5AzprB3J5FKaLXFbXDu_voUGTDaWzmdFdk6XNm7DcuJ4Q0JPDHpj45PiUY9Dsk_v7qPi4t3bb2cfyvPP7z-evTkvjWB8KlsrFTSsbXsqbIvY9ZwrhL5jXIGRvelyED3rFAiorMCW98JKy2vTto1hyI-K1zvvOLd5TmP9FHHQY8wdxxsd0Om_X7y71OtwrbmQDWMiC17dCWK4mm2a9NYlY4eclM1BaCqBQyNzuP9HOc2YEmxBj_9BN2GOPidxSzFRV1Rm6nRHmRhSirbf901BL7ugl13Qf3YhV7y4P-6e__3594Clcq_LPqU5p3UGnu-ATZpC3BMVE5ILteTxcvfeY9C4ji7pi68MaA1AK2hA8l-yatAp</recordid><startdate>20130226</startdate><enddate>20130226</enddate><creator>Stritzker, Jochen</creator><creator>Kirscher, Lorenz</creator><creator>Scadeng, Miriam</creator><creator>Deliolanis, Nikolaos C.</creator><creator>Morscher, Stefan</creator><creator>Symvoulidis, Panagiotis</creator><creator>Schaefer, Karin</creator><creator>Zhang, Qian</creator><creator>Buckel, Lisa</creator><creator>Hess, Michael</creator><creator>Donat, Ulrike</creator><creator>Bradley, William G.</creator><creator>Ntziachristos, Vasilis</creator><creator>Szalay, Aladar A.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130226</creationdate><title>Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer</title><author>Stritzker, Jochen ; Kirscher, Lorenz ; Scadeng, Miriam ; Deliolanis, Nikolaos C. ; Morscher, Stefan ; Symvoulidis, Panagiotis ; Schaefer, Karin ; Zhang, Qian ; Buckel, Lisa ; Hess, Michael ; Donat, Ulrike ; Bradley, William G. ; Ntziachristos, Vasilis ; Szalay, Aladar A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-be89072bbf15ebaadf339a0fd2390c8fcd121f2d90504e5ab3f5e8e36cbb7c2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>antibodies</topic><topic>Biological Sciences</topic><topic>Cancer</topic><topic>clinical trials</topic><topic>fluorescent proteins</topic><topic>Genes</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>image analysis</topic><topic>Imaging</topic><topic>Induced hyperthermia</topic><topic>Infections</topic><topic>Infrared Rays</topic><topic>Lasers</topic><topic>Lymph nodes</topic><topic>Magnetic Resonance Imaging</topic><topic>Melanin</topic><topic>Melanins - biosynthesis</topic><topic>Mice</topic><topic>Neoplasm Metastasis</topic><topic>neoplasms</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>patients</topic><topic>Photoacoustic Techniques - methods</topic><topic>Proteins</topic><topic>Substrates</topic><topic>thermotherapy</topic><topic>Tissues</topic><topic>Tumors</topic><topic>Vaccinia virus</topic><topic>Vaccinia virus - metabolism</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stritzker, Jochen</creatorcontrib><creatorcontrib>Kirscher, Lorenz</creatorcontrib><creatorcontrib>Scadeng, Miriam</creatorcontrib><creatorcontrib>Deliolanis, Nikolaos C.</creatorcontrib><creatorcontrib>Morscher, Stefan</creatorcontrib><creatorcontrib>Symvoulidis, Panagiotis</creatorcontrib><creatorcontrib>Schaefer, Karin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Buckel, Lisa</creatorcontrib><creatorcontrib>Hess, Michael</creatorcontrib><creatorcontrib>Donat, Ulrike</creatorcontrib><creatorcontrib>Bradley, William G.</creatorcontrib><creatorcontrib>Ntziachristos, Vasilis</creatorcontrib><creatorcontrib>Szalay, Aladar A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain. We found that produced melanin is an excellent reporter for optical imaging without addition of substrate. Melanin production also facilitated deep tissue optoacoustic imaging as well as MRI. In addition, melanin was shown to be a suitable target for laser-induced thermotherapy and enhanced oncolytic viral therapy. In conclusion, melanin as a mediator for thermotherapy and reporter for different imaging modalities may soon become a versatile alternative to replace fluorescent proteins also in other biological systems. After ongoing extensive preclinical studies, melanin overproducing oncolytic virus strains might be used in clinical trials in patients with cancer.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>23401518</pmid><doi>10.1073/pnas.1216916110</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals antibodies Biological Sciences Cancer clinical trials fluorescent proteins Genes HeLa Cells Humans Hyperthermia, Induced - methods image analysis Imaging Induced hyperthermia Infections Infrared Rays Lasers Lymph nodes Magnetic Resonance Imaging Melanin Melanins - biosynthesis Mice Neoplasm Metastasis neoplasms Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy patients Photoacoustic Techniques - methods Proteins Substrates thermotherapy Tissues Tumors Vaccinia virus Vaccinia virus - metabolism Viruses |
| title | Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer |
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