Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH

Using a systematic, whole-genome analysis of enhancer activity of human-specific endogenous retroviral inserts (hsERVs), we identified an element, hsERV PRODH, that acts as a tissue-specific enhancer for the PRODH gene, which is required for proper CNS functioning. PRODH is one of the candidate gene...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (48), p.19472-19477
Hauptverfasser:	Suntsova, Maria, Gogvadze, Elena V., Salozhin, Sergey, Gaifullin, Nurshat, Eroshkin, Fedor, Dmitriev, Sergey E., Martynova, Natalia, Kulikov, Kirill, Malakhova, Galina, Tukhbatova, Gulnur, Bolshakov, Alexey P., Ghilarov, Dmitry, Garazha, Andrew, Aliper, Alexander, Cantor, Charles R., Solokhine, Yuri, Roumiantsev, Sergey, Balaban, Pavel, Zhavoronkov, Alex, Buzdin, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Sciences Brain Cell Line Cell lines Cloning, Molecular DNA DNA Methylation DNA Primers - genetics Electrophoretic Mobility Shift Assay Endogenous Retroviruses - genetics Enhancer Elements, Genetic - genetics Enzymes evolution Gene expression Genes Genomes genomic islands Genomics Hippocampus Hippocampus - metabolism Humans Luciferases Mental disorders metabolism Methylation Microarray Analysis Microscopy, Confocal Molecular Sequence Data nervous system diseases Neurological disorders Neurons proline Proline Oxidase - genetics Proline Oxidase - metabolism Promoter regions Schizophrenia Schizophrenia - genetics Sequence Analysis, DNA SOXB1 Transcription Factors - metabolism Tissue samples transcription factors Transfection
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