Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate

The assembly of the three neuronal soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins synaptobrevin 2, syntaxin-1A, and SNAP-25 is the key step that leads to exocytotic fusion of synaptic vesicles. In the fully assembled SNARE complex, these three proteins...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (48), p.19384-19389
Hauptverfasser:	Liang, Binyong, Kiessling, Volker, Tamm, Lukas K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences Cell Line Cell membranes Chemical equilibrium Chromatography, Gel Electron Spin Resonance Spectroscopy Escherichia coli Fluorescence Humans Lipid bilayers Lipids membrane fusion Membranes Micelles Microscopy Microscopy, Fluorescence Models, Molecular Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Mutation NMR Nuclear magnetic resonance nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular P branes Protein Conformation Protein Folding Proteins SNARE proteins SNARE Proteins - metabolism Spin Labels synaptic vesicles Synaptic Vesicles - metabolism Syntaxin 1 - chemistry
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