Ca²⁺ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways

Ca ²⁺ ionophore A23187 is known to induce the acrosome reaction of mammalian spermatozoa, but it also quickly immobilizes them. Although mouse spermatozoa were immobilized by this ionophore, they initiated vigorous motility (hyperactivation) soon after this reagent was washed away by centrifugation....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (46), p.18543-18548
Hauptverfasser:	Tateno, Hiroyuki, Krapf, Dario, Hino, Toshiaki, Sánchez-Cárdenas, Claudia, Darszon, Alberto, Yanagimachi, Ryuzo, Visconti, Pablo E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome reaction Animals bicarbonates Biological Sciences Blotting, Western Calcimycin - pharmacology calcium Calcium - metabolism cAMP-dependent protein kinase centrifugation cyclic AMP Cyclic AMP - metabolism Female Fertilization Fertilization - drug effects Fluorescence Insemination Male Mice Oocytes Ova Phosphorylation Pregnancy Pregnancy Outcome progeny signal transduction Signal Transduction - physiology Sperm capacitation Sperm Capacitation - drug effects Spermatozoa Spermatozoa - drug effects Spermatozoa - physiology tyrosine Washing
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