Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K⁺ channels

K ⁺ channels distinguish K ⁺ from Na ⁺ in the selectivity filter, which consists of four ion-binding sites (S1–S4, extracellular to intracellular) that are built mainly using the carbonyl oxygens from the protein backbone. In addition to ionic discrimination, the selectivity filter regulates the flo...

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