Dominant suppression of inflammation by glycan-hydrolyzed IgG

A unique anti-inflammatory property of IgG, independent of antigen specificity, is described. IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-β- N -acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflamma...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-06, Vol.110 (25), p.10252-10257
Hauptverfasser:	Nandakumar, Kutty Selva, Collin, Mattias, Happonen, Kaisa E, Croxford, Allyson M, Lundström, Susanna L, Zubarev, Roman A, Rowley, Merrill J, Blom, Anna M, Holmdahl, Rikard
Format:	Artikel
Sprache:	eng
Schlagworte:	Andra medicinska och farmaceutiska grundvetenskaper Animals anti-inflammatory activity Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology antigen-antibody complex Antigen-Antibody Complex - immunology Antigens Arthritis Arthritis, Experimental - immunology Arthritis, Experimental - therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy asparagine Basic Medicine Biological Sciences Cartilage - immunology Cattle Clinical Medicine collagen complement Complement C3b - immunology Complement C3b - metabolism Disease Models, Animal endoglycosidase Enzymes Glycoside Hydrolases - immunology Glycoside Hydrolases - metabolism Glycosylation Immune Tolerance - immunology immunoglobulin G Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Immunoglobulins Immunology Infectious Medicine Infektionsmedicin inflammation Inflammation - immunology Inflammation - therapy Inflammatory diseases Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Mice monoclonal antibody Other Basic Medicine Polyclonal antibodies Polysaccharides - immunology Rats Receptors, IgG - immunology Receptors, IgG - metabolism rheumatoid arthritis Streptococcus pyogenes - enzymology Tissue Culture Techniques
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