GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

GPR37 (also known as Pael-R) and GPR37L1 are orphan G protein-coupled receptors that are almost exclusively expressed in the nervous system. We screened these receptors for potential activation by various orphan neuropeptides, and these screens yielded a single positive hit: prosaptide, which promot...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-06, Vol.110 (23), p.9529-9534
Hauptverfasser:	Meyer, Rebecca C., Giddens, Michelle M., Schaefer, Stacy A., Hall, Randy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - drug effects Biological and medical sciences Biological Sciences Blotting, Western Brain Cells Cercopithecus aethiops COS Cells Cyclic AMP - biosynthesis Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Guanosine 5'-O-(3-Thiotriphosphate) - metabolism HEK293 Cells Humans Ligands Mice Mice, Inbred C57BL Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Neurons Orphans Oxidative stress Oxidative Stress - drug effects Parkinson disease Phosphorylation Phosphorylation - drug effects Polysorbates Receptors Receptors, G-Protein-Coupled - metabolism RNA, Small Interfering - genetics Saposins - metabolism Saposins - pharmacology Signal transduction Small interfering RNA Sulfur Radioisotopes - metabolism T cell receptors Vertebrates: nervous system and sense organs
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