Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

Glucocorticoid receptor (GR) antagonism may be of considerable therapeutic value in stress-related psychopathology such as depression. However, blockade of all GR-dependent processes in the brain will lead to unnecessary and even counteractive effects, such as elevated endogenous cortisol levels. Se...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (19), p.7910-7915
Hauptverfasser:	Zalachoras, Ioannis, Houtman, René, Atucha, Erika, Devos, Rene, Tijssen, Ans M. I., Hu, Pu, Lockey, Peter M., Datson, Nicole A., Belanoff, Joseph K., Lucassen, Paul J., Joëls, Marian, de Kloet, E. Ronald, Roozendaal, Benno, Hunt, Hazel, Meijer, Onno C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonism Agonists amygdala Animals antagonists Behavioral neuroscience Biological Sciences Brain - embryology Brain - metabolism Brain - physiology Corticosterone corticotropin-releasing hormone Corticotropin-Releasing Hormone - antagonists & inhibitors cortisol dexamethasone Dexamethasone - pharmacology Gene expression Gene Expression Regulation Glucocorticoid receptors Glucocorticoids Hippocampus - metabolism Ligands Male memory Messenger RNA Mifepristone - pharmacology Neurochemistry Neurogenesis Nuclear Receptor Coactivator 1 - metabolism Peptides - metabolism Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - metabolism Rodents Signal transduction Steroids Steroids - metabolism Stress response Time Factors Transcription, Genetic Two-Hybrid System Techniques
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