Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response

The unfolded protein response (UPR) is a cellular response highly conserved in eukaryotes to obviate accumulation of misfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) catalyzes the cytoplasmic splicing of mRNA encoding bZIP transcription factors to activate the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-04, Vol.110 (14), p.5713-5718
Hauptverfasser:	Mishiba, Kei-ichiro, Nagashima, Yukihiro, Suzuki, Eiji, Hayashi, Noriko, Ogata, Yoshiyuki, Shimada, Yukihisa, Koizumi, Nozomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arabidopsis - genetics Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Biodegradation Biological Sciences Cell death Computational Biology Cytoplasm DNA Fragmentation Endoplasmic Reticulum Stress - physiology Eukaryotes Evans Blue Flowers & plants Gene expression regulation Gene Expression Regulation, Plant - drug effects Gene Expression Regulation, Plant - genetics Genes Messenger RNA Microarray Analysis Mutation - genetics Plant cells Protein Kinases - genetics Protein Kinases - metabolism Proteins Ribonucleic acid RNA RNA Stability - physiology Secretory pathway Seedlings Splicing Tunicamycin - pharmacology Unfolded protein response Unfolded Protein Response - genetics Unfolded Protein Response - physiology
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