Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells

Telomere extension by telomerase is essential for chromosome stability and cell vitality. Here, we report the identification of a splice variant of mammalian heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2), hnRNP A2*, which binds telomeric DNA and telomerase in vitro. hnRNP A2* colocalizes wit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-12, Vol.109 (50), p.20413-20418
Hauptverfasser:	Wang, Feng, Tang, Ming-liang, Zeng, Zhi-xiong, Wu, Ren-yi, Xue, Yong, Hao, Yu-hua, Pang, Dai-Wen, Zhao, Yong, Tan, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Base Sequence Binding Sites - genetics Biological Sciences catalytic activity Cell Line DNA DNA, Complementary - chemistry DNA, Complementary - genetics DNA, Complementary - metabolism Exons G-Quadruplexes Gene expression regulation gene overexpression HeLa Cells Heterogeneous nuclear ribonucleoproteins Heterogeneous-Nuclear Ribonucleoprotein Group A-B - chemistry Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism Humans in vitro studies Liver - metabolism Male mammals Mice Models, Biological Nuclear matrix Nucleic Acid Conformation Nucleic acids Proteins Rats Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism ribonucleoproteins RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics telomerase Telomerase - antagonists & inhibitors Telomerase - genetics Telomerase - metabolism Telomere - metabolism Telomere Homeostasis - physiology Telomeres tissues
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