McClintock’s challenge in the 21st century
In 1950, Barbara McClintock published a Classic PNAS article, “The origin and behavior of mutable loci in maize,” which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2012-12, Vol.109 (50), p.20200-20203 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Fedoroff, Nina V |
| description | In 1950, Barbara McClintock published a Classic PNAS article, “The origin and behavior of mutable loci in maize,” which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring. |
| doi_str_mv | 10.1073/pnas.1215482109 |
| format | Article |
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| subjects | Alleles Biological Sciences chromosome aberrations Chromosome Breakage Chromosomes Chromosomes, Plant - genetics Corn crossing DNA DNA Transposable Elements - genetics Epigenesis, Genetic Epigenetics Genes Genetic loci Genetic research Genetic transposition genome Genome, Plant Genomes History, 20th Century History, 21st Century loci McClintock McClintock, Barbara Molecular Biology - history Molecular Biology - trends Phenotype PNAS CLASSIC PERSPECTIVE PNAS Classics Scientists transposition (genetics) Transposons Zea mays - genetics |
| title | McClintock’s challenge in the 21st century |
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