Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival

The promise of islet cell transplantation cannot be fully realized in the absence of improvements in engraftment of resilient islets. The marginal mass of islets surviving the serial peritransplant insults may lead to exhaustion and thereby contribute to an unacceptably high rate of intermediate and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-09, Vol.109 (38), p.15443-15448
Hauptverfasser:	Koulmanda, Maria, Bhasin, Manoj, Fan, Zhigang, Hanidziar, Dusan, Goel, Nipun, Putheti, Prabhakar, Movahedi, Babak, Libermann, Towia A, Strom, Terry B
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - metabolism Animals Biological Sciences Biomedical research Cell Survival cell transplantation clinical trials Diabetes Diabetes complications Diabetes Mellitus, Experimental - therapy Diabetes Mellitus, Type 1 - therapy gene expression regulation Genes hosts humans Immune System Immunology Inflammation Insulin - metabolism Islet cells Islets of Langerhans Islets of Langerhans - cytology Islets of Langerhans Transplantation - methods Male Mice Mice, Inbred C57BL Molecules Protease inhibitors Rodents Survival analysis Tissue grafting transcription (genetics) transcription factor NF-kappa B Transplantation Transplants & implants Treatment Outcome tumor necrosis factor-alpha Type 1 diabetes mellitus
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