Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation

Decoupling of transcription and translation during postmeiotic germ cell differentiation is critical for successful spermatogenesis. Here we establish that the interaction between microRNAs and actin-associated protein Arpc5 sets the stage for an elaborate translational control mechanism by facilita...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (15), p.5750-5755
Hauptverfasser:	Chang, Yao-Fu, Lee-Chang, Jennifer S, Imam, J. Saadi, Buddavarapu, Kalyan Chakravarthy, Subaran, Sarah S, Sinha-Hikim, Amiya P, Gorospe, Myriam, Rao, Manjeet K
Format:	Artikel
Sprache:	eng
Schlagworte:	abnormalities Actin-Related Protein 2-3 Complex Actin-Related Protein 2-3 Complex - metabolism Animals Base Sequence Biological Sciences cell differentiation Cell Differentiation - genetics Cells Chromatin Chromatin - metabolism Enzyme Activation Gene Expression Regulation genetics germ Germ cells Haploidy HeLa Cells Humans Male Meiosis Meiosis - genetics Messenger RNA metabolism Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Mitochondria Molecular Sequence Data pathology Protamines Protamines - metabolism Protein Binding Protein Biosynthesis Proteins Reproduction Ribonuclease III Ribonuclease III - metabolism Ribonucleic acid Ribosomes Ribosomes - metabolism RNA RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Somatic cells Sperm Sperm Head Sperm Head - metabolism Sperm Head - pathology Sperm Head - ultrastructure Spermatids spermatogenesis Spermatozoa Spermatozoa - metabolism Spermatozoa - pathology Testis Testis - abnormalities Testis - pathology Testis - ultrastructure translation (genetics) ultrastructure
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