Direct observation of multiple misfolding pathways in a single prion protein molecule

Protein misfolding is a ubiquitous phenomenon associated with a wide range of diseases. Single-molecule approaches offer a powerful tool for deciphering the mechanisms of misfolding by measuring the conformational fluctuations of a protein with high sensitivity. We applied single-molecule force spec...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (14), p.5283-5288
Hauptverfasser:	Yu, Hao, Liu, Xia, Neupane, Krishna, Gupta, Amar Nath, Brigley, Angela M, Solanki, Allison, Sosova, Iveta, Woodside, Michael T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Amyloids Biochemistry Biological Sciences DNA Fluorescence Histograms metabolism methods Molecules mutants Mutation Prions Prions - metabolism Protein Folding Protein refolding Proteins Spectroscopy Spectrum Analysis Spectrum Analysis - methods
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