Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish

Photoreceptor cell death accompanying many retinal degenerative disorders results in irreversible loss of vision in humans. However, the precise molecular pathway that executes cell death is not known. Our results from a Drosophila model of retinal degeneration corroborate previously reported findin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-03, Vol.109 (10), p.E605-E612
Hauptverfasser:	Chinchore, Yashodhan, Gerber, Gloria F, Dolph, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Animals, Genetically Modified Apoptosis Biological Sciences Caspases - metabolism Cell Death Drosophila Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Female genes genetic background Gram-negative bacteria humans immune response Immune System Male Models, Biological Models, Genetic NF-kappa B - metabolism Photoreceptor Cells, Invertebrate - metabolism photoreceptors PNAS Plus Protein Structure, Tertiary Signal Transduction toxicity transcription factors Transcription Factors - metabolism vision
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