Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region

The mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase, a key component of the Carma1/Bcl10/MALT1 signalosome, is critical for NF-κB signaling in multiple contexts. MALT1 is thought to function as a scaffold and protease to promote signaling; however, the biochemical and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-12, Vol.108 (52), p.21004-21009
Hauptverfasser:	Yu, Jong W, Jeffrey, Philip D, Ha, Jun Yong, Yang, Xiaolu, Shi, Yigong
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Amino acids Bcl-10 protein Biological Sciences Caspase caspases Caspases - chemistry Crystal structure Crystallization Dimerization Dimers Humans Hydrogen bonding Hydrogen bonds Immunoglobulins Lymphoma Models, Molecular Mucosa associated lymphoid tissue lymphoma Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Neoplasm Proteins - chemistry NF- Kappa B protein paracaspases peptide inhibitors Proteases Protein Conformation Protein subunits Proteinase scaffolds Signal transduction signalosomes Substrate specificity T lymphocytes Tissues Translocation Ubiquitins
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