Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

Munc18-1 and Syntaxin1 are essential proteins for SNARE-mediated neurotransmission. Munc18-1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding closed Syntaxin1, and as a fusion protein that binds SNARE complexes in a Syntaxin1 N-peptide dependent manne...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-01, Vol.108 (3), p.1040-1045
Hauptverfasser:	Hu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M., Martin, Jennifer L., Südhof, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological Sciences Cell membranes Circular Dichroism Crystal structure Crystallography Crystals Exocytosis Hydrogen bonds Models, Molecular Molecular Sequence Data Molecular structure Multiprotein Complexes - metabolism Munc18 Proteins - chemistry Munc18 Proteins - metabolism PC12 cells Peptides Physiological regulation Plasma interactions Protein Binding Protein Conformation Proteins Sequence Alignment SNARE proteins SNARE Proteins - metabolism Synaptic Transmission - physiology Syntaxin 1 - metabolism
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