Heterotrimeric G protein β1γ2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane

Few experimental techniques can assess the orientation of peripheral membrane proteins in their native environment. Sum Frequency Generation (SFG) vibrational spectroscopy was applied to study the formation of the complex between G protein-coupled receptor (GPCR) kinase 2 (GRK2) and heterotrimeric G...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-09, Vol.108 (37), p.E667-E673
Hauptverfasser:	Boughton, Andrew P, Yang, Pei, Tesmer, Valerie M, Ding, Bei, Tesmer, John J. G, Chen, Zhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences crystal structure G-proteins kinases lipids membrane proteins methodology phosphotransferases (kinases) Physical Sciences PNAS Plus receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!