Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development

Sonic hedgehog (Shh) signaling plays diverse roles during animal development and adult tissue homeostasis through differential regulation of Gli family transcription factors. Dysregulated Shh signaling activities have been linked to birth defects and tumorigenesis. Here we report that Brg, an ATP-de...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-08, Vol.108 (31), p.12758-12763
Hauptverfasser:	Zhan, Xiaoming, Shi, Xuanming, Zhang, Zilai, Chen, Yu, Wu, Jiang I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase adenosinetriphosphatase adult development Animals Antibodies Biological Sciences Birth defects carcinogenesis Cells, Cultured Chromatin Chromatin Assembly and Disassembly - genetics Chromatin Assembly and Disassembly - physiology congenital abnormalities DNA Helicases - genetics DNA Helicases - metabolism Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Female fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene activation Gene expression Gene expression regulation Gene Expression Regulation, Developmental Genes Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Hedgehogs HEK293 Cells histone deacetylase Histone Deacetylases - genetics Histone Deacetylases - metabolism Homeostasis Humans Immunoblotting In Situ Hybridization Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Male Mice Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural Stem Cells - cytology Neural Stem Cells - metabolism neurodevelopment Neurons Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - genetics Signal Transduction - physiology Small mammals Telencephalon Telencephalon - cytology Telencephalon - embryology Telencephalon - metabolism Tissue Culture Techniques transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional regulatory elements Zinc Finger Protein Gli3
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