c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

The tyrosine kinase c-Met promotes the formation and malignant progression of multiple cancers. It is well known that c-Met hyperactivation increases tumorigenicity and tumor cell resistance to DNA damaging agents, properties associated with tumor-initiating stem cells. However, a link between c-Met...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-06, Vol.108 (24), p.9951-9956
Hauptverfasser:	Li, Yunqing, Li, Angela, Glas, Martin, Lal, Bachchu, Ying, Mingyao, Sang, Yingying, Xia, Shuli, Trageser, Daniel, Guerrero-Cázares, Hugo, Eberhart, Charles G., Quiñones-Hinojosa, Alfredo, Scheffler, Bjorn, Laterra, John
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antigens, CD - genetics Antigens, CD - metabolism Biological Sciences Cancer Cell growth Cellular Reprogramming Differentiation DNA damage Embryo cells Flow Cytometry Gene expression Gene Expression Regulation, Neoplastic - drug effects Genotype & phenotype Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology glioblastoma cells Glycoproteins - genetics Glycoproteins - metabolism Hepatocytes Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunoblotting Indoles - pharmacology Induced pluripotent stem cells Kinases Mice Mice, SCID Nanog Homeobox Protein Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neural stem cells Neurons neurospheres Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Peptides - genetics Peptides - metabolism Phenotype Phenotypes Piperazines - pharmacology Protein-tyrosine kinase Proteins Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction Somatic cells SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Sulfonamides - pharmacology Transcription factors Transplantation, Heterologous Tumor cells Tumor Cells, Cultured Tumorigenicity Tumors
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