End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment

The axon initial segment (AIS) plays a key role in maintaining the molecular and functional polarity of the neuron. The relationship between the AIS architecture and the microtubules (MTs) supporting axonal transport is unknown. Here we provide evidence that the MT plus-end-binding (EB) proteins EB1...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-05, Vol.108 (21), p.8826-8831
Hauptverfasser:	Leterrier, Christophe, Vacher, HÃ©lÃ¨ne, Fache, Marie-Pierre, d'Ortoli, StÃ©phanie Angles, Castets, Francis, Autillo-Touati, Amapola, Dargent, BÃ©nÃ©dicte
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ankyrins Ankyrins - metabolism axonal transport Axons Axons - metabolism Binding sites Biological Sciences Cell Polarity Cells Comets COS cells Dendrites Life Sciences Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Molecular chemistry Neurobiology Neurons Neurons - ultrastructure Neurons and Cognition Plasmids Protein Binding Proteins Rats Rats, Wistar scaffolding proteins Scaffolds Up regulation
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