MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling

Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased expression during neural differentiation. However, the role o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-02, Vol.107 (5), p.1876-1881
Hauptverfasser:	Zhao, Chunnian, Sun, GuoQiang, Li, Shengxiu, Lang, Ming-Fei, Yang, Su, Li, Wendong, Shi, Yanhong
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals Binding Sites - genetics Biological Sciences Brain - cytology Brain - embryology Brain - metabolism Cell cycle Cell Differentiation Cell division Cell Proliferation Cells Cells, Cultured Cellular differentiation Cyclin D1 - genetics Cyclin D1 - metabolism Cyclins Electroporation Female Gene expression Gene expression regulation Mice MicroRNA MicroRNAs - genetics Neural stem cells Neurons Neurons - cytology Neurons - metabolism Pregnancy Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Ribonucleic acid RNA Signal Transduction Stem cells Untranslated regions
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