Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia

The mechanism(s) by which anesthetics reversibly suppress consciousness are incompletely understood. Previous functional imaging studies demonstrated dynamic changes in thalamic and cortical metabolic activity, as well as the maintained presence of metabolically defined functional networks despite t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (49), p.21170-21175
Hauptverfasser:	Breshears, Jonathan D., Roland, Jarod L., Sharma, Mohit, Gaona, Charles M., Freudenburg, Zachary V., Tempelhoff, Rene, Avidan, Michael S., Leuthardt, Eric C., Raichle, Marcus E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia - methods Anesthetics Architecture Biological Sciences Brain Cerebral Cortex - drug effects Cerebral Cortex - physiology Consciousness - drug effects Correlation coefficients Correlations Covariance Electrodes Electroencephalography - methods Electrophysiological Phenomena Electrophysiology Evoked Potentials, Somatosensory - drug effects Human subjects Humans Metabolism Propofol - pharmacology Statistical variance Studies Thalamus - drug effects Thalamus - physiology Unconsciousness
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