β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that acts as a master metabolic regulator to maintain cellular energy balance following increased energy demand and increases in the AMP/ATP ratio. This regulation provides dynamic control of energy metabolism, matching energy supply wit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-11, Vol.107 (45), p.19237-19241
Hauptverfasser:	Oakhill, Jonathan S, Chen, Zhi-Ping, Scott, John W, Steel, Rohan, Castelli, Laura A, Ling, Naomi, Macaulay, S. Lance, Kemp, Bruce E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - metabolism Allosteric Regulation AMP-Activated Protein Kinases - metabolism AMP-Activated Protein Kinases - physiology Animals Binding sites Biological Sciences Cell Line Cell membranes Cercopithecus aethiops COS Cells Crystal structure Energy Metabolism Glucose - metabolism Insecta Metabolic stress Myristic Acid - metabolism Phosphatases Phosphorylation Protein metabolism Protein Subunits - metabolism Proteins
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