Consensus motif for integrin transmembrane helix association

Interactions between transmembrane (TM) helices play an important role in the regulation of diverse biological functions. For example, the TM helices of integrins are believed to interact heteromerically in the resting state; disruption of this interaction results in integrin activation and cellular...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (2), p.703-708
Hauptverfasser:	Berger, Bryan W, Kulp, Daniel W, Span, Lisa M, DeGrado, Jessica L, Billings, Paul C, Senes, Alessandro, Bennett, Joel S, DeGrado, William F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological Sciences Cell adhesion Cell adhesion & migration Cell Line Cell membranes Cells Collagens Consensus Sequence Dimerization Dimers DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Escherichia coli - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Fibrosis Genetic mutation HEK293 cells Humans Integrin alpha Chains - chemistry Integrin alpha Chains - genetics Integrin beta Chains - chemistry Integrin beta Chains - genetics Integrins Jurkat Cells Ligands Membrane proteins Membranes Models, Molecular Molecular Sequence Data Molecular structure Mutation Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Peptide Fragments - chemistry Promoter Regions, Genetic Protein Conformation Protein Subunits - chemistry Protein Subunits - genetics Proteins Sequence Alignment Sequence Homology, Amino Acid
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