Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L. This kinase promotes mitotic entry and maintenance in human cells by inhibiting protein phosphatase 2A (PP2A), a phosphatase that dephosphoryl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-07, Vol.107 (28), p.12564-12569
Hauptverfasser:	Burgess, Andrew, Vigneron, Suzanne, Brioudes, Estelle, Labbé, Jean-Claude, Lorca, Thierry, Castro, Anna, Hunt, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Biological Sciences Cell Cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle - physiology Cell division Cell separation Cells Cyclin B Cyclin B - metabolism Cyclin B1 Cyclins Cytokines Daughter cells Enzyme kinetics Enzymes HeLa cells Humans Kinases Life Sciences Metaphase Mitosis Mitosis - drug effects Okadaic Acid Okadaic Acid - metabolism Okadaic Acid - pharmacology Phenotypes Phosphatases Phosphoric Monoester Hydrolases Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphorylation Protein Phosphatase 2 Protein Phosphatase 2 - metabolism Protein-Serine-Threonine Kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Proteins - genetics Proteins - metabolism RNA, Small Interfering RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Small interfering RNA
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