miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

Medulloblastomas (MBs) are the most common brain tumors in children. Some are thought to originate from cerebellar granule neuron progenitors (GNPs) that fail to undergo normal cell cycle exit and differentiation. Because microRNAs regulate numerous aspects of cellular physiology and development, we...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (8), p.2812-2817
Hauptverfasser:	Uziel, Tamar, Karginov, Fedor V, Xie, Suqing, Parker, Joel S, Wang, Yong-Dong, Gajjar, Amar, He, Lin, Ellison, David, Gilbertson, Richard J, Hannon, Gregory, Roussel, Martine F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain Cancer Cell cycle Cerebellum - growth & development Cerebellum - metabolism Developmental biology Gene expression Genetic mutation Hedgehog Proteins - metabolism Humans Medulloblastoma Medulloblastoma - genetics Medulloblastoma - metabolism Medulloblastoma - pathology Mice MicroRNA MicroRNAs - genetics Multigene Family Neurons Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Rodents Signal Transduction Signatures Tumors
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