PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

Mitochondrial biogenesis occurs in response to increased cellular ATP demand. The mitochondrial electron transport chain requires molecular oxygen to produce ATP. Thus, increased ATP generation after mitochondrial biogenesis results in increased oxygen demand that must be matched by a corresponding...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (7), p.2188-2193
Hauptverfasser:	O'Hagan, Kathleen A, Cocchiglia, Sinead, Zhdanov, Alexander V, Tambawala, Murtaza M, Cummins, Eoin P, Monfared, Mona, Agbor, Terence A, Garvey, John F, Papkovsky, Dmitri B, Taylor, Cormac T, Allan, Bernard B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell lines Gene expression Genes HeLa cells Hypoxia Messenger RNA Oxygen Oxygen consumption PC12 cells Skeletal muscle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!