VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

Breakdown of the blood-brain barrier (BBB) is an early and significant event in CNS inflammation. Astrocyte-derived VEGF-A has been implicated in this response, but the underlying mechanisms remain unresolved. Here, we identify the endothelial transmembrane tight junction proteins claudin-5 (CLN-5)...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (6), p.1977-1982
Hauptverfasser:	Argaw, Azeb Tadesse, Gurfein, Blake T, Zhang, Yueting, Zameer, Andleeb, John, Gareth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Biological Sciences Blood Blood brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain Cattle Cell culture Cell lines Cell Membrane Permeability Cells, Cultured Central nervous system Central Nervous System - pathology Cerebral Cortex Disease Models, Animal Down regulation Down-Regulation - genetics Encephalomyelitis, Autoimmune, Experimental - pathology Endothelial cells Endothelium, Vascular - cytology Epithelial cells Gene expression Humans Inflammation Inflammatory diseases Lysosomal Membrane Proteins Membrane Proteins - genetics Membrane Proteins - physiology Membranes Mice Nervous system Occludin Proteins Spinal cord Tight junctions Vascular Endothelial Growth Factor A - pharmacology
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