β₁ integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

Inhibiting the α₄ subunit of the integrin heterodimers α₄β₁ and α₄β₇ with the monoclonal antibody natalizumab is an effective treatment for multiple sclerosis (MS). However, the pharmacological action of natalizumab is not understood conclusively. Previous studies suggested that natalizumab inhibits...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (6), p.1920-1925
Hauptverfasser:	Bauer, Martina, Brakebusch, Cord, Coisne, Caroline, Sixt, Michael, Wekerle, Hartmut, Engelhardt, Britta, Fässler, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies B lymphocytes Biological Sciences Cell adhesion Cell lines Central nervous system Endothelial cells Integrins Leukocytes Spinal cord T lymphocytes
Online-Zugang:	Volltext
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