integrin α₄β₇ forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

Both activated and resting CD4⁺ T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin α₄β₇ (α₄β₇), the gut mucosal homing receptor. We find that α₄β₇high CD4⁺ T cells are mo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (49), p.20877-20882
Hauptverfasser:	Cicala, Claudia, Martinelli, Elena, McNally, Jonathan P, Goode, Diana J, Gopaul, Ravindra, Hiatt, Joseph, Jelicic, Katija, Kottilil, Shyamasundaran, Macleod, Katilyn, O'Shea, Angeline, Patel, Nikita, Van Ryk, Donald, Wei, Danlan, Pascuccio, Massimiliano, Yi, Ling, McKinnon, Lyle, Izulla, Preson, Kimani, Joshua, Kaul, Rupert, Fauci, Anthony S, Arthos, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell membranes Genitalia HIV HIV 1 Infections Integrins Mucosa Receptors Sexual transmission T lymphocytes
Online-Zugang:	Volltext
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