CRF system recruitment mediates dark side of compulsive eating

Dieting to control body weight involves cycles of deprivation from palatable food that can promote compulsive eating. The present study shows that rats withdrawn from intermittent access to palatable food exhibit overeating of palatable food upon renewed access and an affective withdrawal-like state...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-11, Vol.106 (47), p.20016-20020
Hauptverfasser:	Cottone, Pietro, Sabino, Valentina, Roberto, Marisa, Bajo, Michal, Pockros, Lara, Frihauf, Jennifer B, Fekete, Eva M, Steardo, Luca, Rice, Kenner C, Grigoriadis, Dimitri E, Conti, Bruno, Koob, George F, Zorrilla, Eric P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - cytology Amygdala - metabolism Animals Antagonist drugs Behavior, Addictive - metabolism Behavior, Addictive - psychology Behavior, Animal - physiology Biological Sciences Compulsive Behavior Corticotropin-Releasing Hormone - metabolism Diet Dosage Eating - physiology Eating - psychology Eating disorders Electrophysiology Emotions Food Food access Food intake Male Maze Learning Messenger RNA Obesity Pyrimidines - metabolism Rats Rats, Wistar Receptors Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - metabolism Reward Stress, Psychological - metabolism Stress, Psychological - psychology Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - psychology Weight control
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