Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

Blocking conformational changes in biologically active proteins holds therapeutic promise. Inspired by the susceptibility of viral entry to inhibition by synthetic peptides that block the formation of helix-helix interactions in viral envelope proteins, we developed a computational approach for pred...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-08, Vol.106 (33), p.13797-13801
Hauptverfasser:	Kliger, Yossef, Levy, Ofer, Oren, Anat, Ashkenazy, Haim, Tiran, Zohar, Novik, Amit, Rosenberg, Avi, Amir, Anat, Wool, Assaf, Toporik, Amir, Schreiber, Ehud, Eshel, Dani, Levine, Zurit, Cohen, Yossi, Nold-Petry, Claudia, Dinarello, Charles A, Borukhov, Itamar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antagonists Antineoplastic Agents - pharmacology Biochemistry Biological Sciences Blood Cells Chaperones Clusterin Clusterin - chemistry Computational Biology - methods Computer applications Correlation analysis Cytokines Data processing Endotoxins Envelope protein Female Fourier transformations Fourier transforms glycoprotein gp96 Glycoproteins Heat shock proteins HIV 1 Interleukin 1 Interleukin 6 Interleukin 8 Interleukin-1beta - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lung cancer Medical treatment Membrane Glycoproteins - chemistry Mice Mice, Nude Molecular Chaperones Molecules Mutation Neoplasm Transplantation Paclitaxel Peptides Peptides - chemistry Periodicity Protein Conformation Proteins Rodents synthetic peptides Tumor necrosis factor-a Tumor Necrosis Factor-alpha - metabolism Viruses Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!