Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-07, Vol.106 (30), p.12295-12300
Hauptverfasser:	Eustáquio, Alessandra S, McGlinchey, Ryan P, Liu, Yuan, Hazzard, Christopher, Beer, Laura L, Florova, Galina, Alhamadsheh, Mamoun M, Lechner, Anna, Kale, Andrew J, Kobayashi, Yoshihisa, Reynolds, Kevin A, Moore, Bradley S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - classification Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological Sciences Chromatography, High Pressure Liquid Cladribine - chemistry Cladribine - metabolism Cloning, Molecular Gene Order Genome, Bacterial - genetics Kinetics Lactones - chemistry Lactones - metabolism Malonyl Coenzyme A - metabolism Marine Micromonosporaceae - genetics Micromonosporaceae - metabolism Models, Chemical Molecular Sequence Data Molecular Structure Multigene Family Mutation Phylogeny Polyketide Synthases - genetics Polyketide Synthases - metabolism Pyrroles - chemistry Pyrroles - metabolism S-Adenosylmethionine - metabolism Sequence Analysis, DNA Substrate Specificity
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