Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

Binding of activated protein C (APC) to cells triggers multiple beneficial cytoprotective activities that suppress apoptosis, inflammation, and endothelial barrier breakdown. One paradigm for APC's signaling emphasizes its binding to endothelial cell protein C receptor (EPCR) and subsequent pro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-01, Vol.106 (1), p.274-279
Hauptverfasser:	Yang, Xia V, Banerjee, Yajnavalka, Fernández, José A, Deguchi, Hiroshi, Xu, Xiao, Mosnier, Laurent O, Urbanus, Rolf.T, de Groot, Phillip G, White-Adams, Tara C, McCarty, Owen J.T, Griffin, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Binding sites Biological Sciences Blood Coagulation Factors Cells Glycogen Synthase Kinase 3 - metabolism Humans Kinases LDL-Receptor Related Proteins Monocytes - cytology Nerve Tissue Proteins - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proteases Protein Binding Protein C - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Receptors, Cell Surface Receptors, Lipoprotein - metabolism Signal Transduction U937 Cells
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