Folding kinetics of the human prion protein probed by temperature jump

Temperature-jump perturbation was used to examine the relaxation kinetics of folding of the human prion protein. Measured rates were very fast ([almost equal to]3,000 s⁻¹), with the extrapolated folding rate constant at [almost equal to]20 °C in physiological conditions reaching 20,000 s⁻¹. By a mut...

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