Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin

Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS), confers protection against malaria in Africa. AS children infected with Plasmodium falciparum are less likely than AA children to suffer the symptoms or severe manifestations of malaria, and they often c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-01, Vol.105 (3), p.991-996
Hauptverfasser:	Cholera, Rushina, Brittain, Nathaniel J, Gillrie, Mark R, Lopera-Mesa, Tatiana M, Diakité, Séidina A.S, Arie, Takayuki, Krause, Michael A, Guindo, Aldiouma, Tubman, Abby, Fujioka, Hisashi, Diallo, Dapa A, Doumbo, Ogobara K, Ho, May, Wellems, Thomas E, Fairhurst, Rick M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Biological variation Blood Cell Adhesion Cells Cells, Cultured Children Endothelial Cells - cytology Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Erythrocytes - ultrastructure Hemoglobin Hemoglobin SC Disease - metabolism Hemoglobin SC Disease - parasitology Hemoglobin SC Disease - pathology Hemoglobin, Sickle - metabolism Hemoglobins Humans Macrophages Malaria Microcirculation - cytology Microscopy, Electron, Transmission Monocytes Monocytes - cytology Parasites Parasitism Plasmodium falciparum Plasmodium falciparum - physiology Polymorphism Protozoan Proteins - metabolism Sickle Cell Trait - metabolism Sickle Cell Trait - parasitology Sickle Cell Trait - pathology Sickles Virology
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