Structural Determinants for Membrane Association and Dynamic Organization of the Hepatitis C Virus NS3-4A Complex

Hepatitis C virus (HCV) NS3-4A is a membrane-associated multifunctional protein harboring serine protease and RNA helicase activities. It is an essential component of the HCV replication complex and a prime target for antiviral intervention. Here, we show that membrane association and structural org...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (38), p.14545-14550
Hauptverfasser:	Brass, Volker, Berke, Jan Martin, Montserret, Roland, Blum, Hubert E., Penin, François, Moradpour, Darius
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Antivirals Biological Sciences Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Crystal structure DNA Mutational Analysis Hepacivirus Hepacivirus - chemistry Hepacivirus - enzymology Hepacivirus - metabolism Hepatitis Hepatitis C Hepatitis C virus Membranes Microscopy Models, Molecular Molecular Sequence Data P branes Polyproteins Proteases Protein Structure, Secondary Protein Structure, Tertiary Proteins RNA RNA-protein interactions Topology Viral Matrix Proteins - chemistry Viral Matrix Proteins - metabolism Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism
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