Transmission of Y chromosomes from XY female mice was made possible by the replacement of cytoplasm during oocyte maturation

The B6.YTIR sex-reversed female mouse is anatomically normal at young ages but fails to produce offspring. We have previously shown that its oocytes go through the meiotic cell cycle up to the second metaphase; however, the meiotic spindle is not properly organized, the second meiotic division goes...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (37), p.13918-13923
Hauptverfasser:	Obata, Yayoi, Villemure, Michele, Kono, Tomohiro, Taketo, Teruko
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal reproduction Animals Biological Sciences Cell cycle Cell Differentiation Cell division Cells, Cultured Chromosomes Control groups Cytoplasm Cytoplasm - metabolism DNA-Binding Proteins - genetics Embryogenesis Female Fertilization Karyotype Karyotyping Male Meiosis Metaphase Mice Microtubules Mitotic spindle apparatus Nuclei Oocytes Oocytes - cytology Oocytes - metabolism Polymorphism, Genetic - genetics Reproductive technologies Rodents Sex chromosomes Spindle Apparatus - genetics Spindles Transcription Factors - genetics X Chromosome - genetics Y chromosome Y Chromosome - genetics
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