Dependence of antibody-mediated presentation of antigen on FcRn
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barri...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2008-07, Vol.105 (27), p.9337-9342 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 105 |
| creator | Qiao, Shuo-Wang Kobayashi, Kanna Johansen, Finn-Eirik Sollid, Ludvig M Andersen, Jan Terje Milford, Edgar Roopenian, Derry C Lencer, Wayne I Blumberg, Richard S |
| description | The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes. |
| doi_str_mv | 10.1073/pnas.0801717105 |
| format | Article |
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It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0801717105</identifier><identifier>PMID: 18599440</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Antibodies ; Antigen Presentation - immunology ; Antigen-Antibody Complex - immunology ; Antigen-Presenting Cells - cytology ; Antigen-Presenting Cells - immunology ; Antigens ; Binding sites ; Biological Sciences ; Cell Proliferation ; Cells ; Circles ; Cytokines ; Dendritic Cells - cytology ; Dendritic Cells - immunology ; Fc receptors ; Hematopoietic System - cytology ; Hematopoietic System - immunology ; Hemocyanins - immunology ; Histocompatibility Antigens Class I - immunology ; Humans ; Immunoglobulin G - immunology ; Ligands ; Lysosomal Membrane Proteins - immunology ; Lysosomes ; Lysosomes - immunology ; Mice ; Molecules ; Monocytes - cytology ; Monocytes - immunology ; Mutation - genetics ; Ova ; Protein Binding ; Protein Processing, Post-Translational ; Protein Transport ; Receptors, Fc - immunology ; T lymphocytes ; T-Lymphocytes - cytology ; T-Lymphocytes - immunology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2008-07, Vol.105 (27), p.9337-9342</ispartof><rights>Copyright 2008 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Jul 8, 2008</rights><rights>2008 by The National Academy of Sciences of the USA</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-11836296d1de08714a07619a18d46577e39ba3fe243b12d4c011f8e08a0303d93</citedby><cites>FETCH-LOGICAL-c618t-11836296d1de08714a07619a18d46577e39ba3fe243b12d4c011f8e08a0303d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/105/27.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25462970$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25462970$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18599440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiao, Shuo-Wang</creatorcontrib><creatorcontrib>Kobayashi, Kanna</creatorcontrib><creatorcontrib>Johansen, Finn-Eirik</creatorcontrib><creatorcontrib>Sollid, Ludvig M</creatorcontrib><creatorcontrib>Andersen, Jan Terje</creatorcontrib><creatorcontrib>Milford, Edgar</creatorcontrib><creatorcontrib>Roopenian, Derry C</creatorcontrib><creatorcontrib>Lencer, Wayne I</creatorcontrib><creatorcontrib>Blumberg, Richard S</creatorcontrib><title>Dependence of antibody-mediated presentation of antigen on FcRn</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. 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It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>18599440</pmid><doi>10.1073/pnas.0801717105</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies Antigen Presentation - immunology Antigen-Antibody Complex - immunology Antigen-Presenting Cells - cytology Antigen-Presenting Cells - immunology Antigens Binding sites Biological Sciences Cell Proliferation Cells Circles Cytokines Dendritic Cells - cytology Dendritic Cells - immunology Fc receptors Hematopoietic System - cytology Hematopoietic System - immunology Hemocyanins - immunology Histocompatibility Antigens Class I - immunology Humans Immunoglobulin G - immunology Ligands Lysosomal Membrane Proteins - immunology Lysosomes Lysosomes - immunology Mice Molecules Monocytes - cytology Monocytes - immunology Mutation - genetics Ova Protein Binding Protein Processing, Post-Translational Protein Transport Receptors, Fc - immunology T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology |
| title | Dependence of antibody-mediated presentation of antigen on FcRn |
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