Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: A urocortin₁-independent mechanism

A common expression of neuroadaptations induced by repeated exposure to addictive drugs is a persistent sensitized behavioral response to their stimulant properties. Neuroplasticity underlying drug-induced sensitization has been proposed to explain compulsive drug pursuit and consumption characteris...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-07, Vol.105 (26), p.9070-9075
Hauptverfasser:	Pastor, Raúl, McKinnon, Carrie S, Scibelli, Angela C, Burkhart-Kasch, Sue, Reed, Cheryl, Ryabinin, Andrey E, Coste, Sarah C, Stenzel-Poore, Mary P, Phillips, Tamara J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Biological - drug effects Addiction Adrenocorticotropic Hormone - blood Alcohols Animals Behavior, Animal - drug effects Behavioral neuroscience Biological Sciences Dosage Ethanol Ethanol - administration & dosage Ethanol - pharmacology Gene Deletion Genotypes Locomotion Mice Mice, Inbred C57BL Mice, Knockout Mifepristone - pharmacology Nervous System Physiological Phenomena - drug effects Pretreatment Psychomotor Performance - drug effects Pyrimidines - pharmacology Pyrroles - pharmacology Receptors Receptors, Corticotropin-Releasing Hormone - metabolism Sensitization Urocortins - metabolism
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