Comprehensive Screening for Antigens Overexpressed on Carcinomas via Isolation of Human mAbs That May Be Therapeutic

Although several murine mAbs that have been humanized became useful therapeutic agents against a few malignancies, therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags) can become useful targets. In the present study we e...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-05, Vol.105 (20), p.7287-7292
Hauptverfasser:	Kurosawa, Gene, Akahori, Yasushi, Morita, Miwa, Sumitomo, Mariko, Sato, Noriko, Muramatsu, Chiho, Eguchi, Keiko, Matsuda, Kazuki, Takasaki, Akihiko, Tanaka, Miho, Iba, Yoshitaka, Hamada-Tsutsumi, Susumu, Ukai, Yoshinori, Shiraishi, Mamoru, Suzuki, Kazuhiro, Kurosawa, Maiko, Fujiyama, Sally, Takahashi, Nobuhiro, Kato, Ryoichi, Mizoguchi, Yoshikazu, Shamoto, Mikihiro, Tsuda, Hiroyuki, Sugiura, Mototaka, Hattori, Yoshinobu, Miyakawa, Shuichi, Shiroki, Ryoichi, Hoshinaga, Kiyotaka, Hayashi, Nobuhiro, Sugioka, Atsushi, Kurosawaam, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - chemistry Antigens Antigens, Neoplasm - chemistry Antineoplastic Agents - pharmacology Bacteriophages Biological Sciences Cancer Carcinoma Carcinoma - diagnosis Carcinoma - immunology Cell Line, Tumor Cell lines Cells Cloning Humans Immunoglobulin G - metabolism Immunology Immunotherapy - instrumentation Immunotherapy - methods Libraries Medical screening Medical treatment Mice Mice, Nude Models, Biological Neoplasms - diagnosis Neoplasms - immunology Peptide Library Receptor, Epidermal Growth Factor - metabolism Squamous cell carcinoma Tumor cell line Tumors
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