Molecular assembly for high-performance bivalent nucleic acid inhibitor

It is theorized that multivalent interaction can result in better affinity and selectivity than monovalent interaction in the design of high-performance ligands. Accordingly, biomolecular engineers are increasingly taking advantage of multivalent interactions to fabricate novel molecular assemblies,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-04, Vol.105 (15), p.5664-5669
Hauptverfasser:	Kim, Youngmi, Cao, Zehui, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticoagulants Antidotes Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - toxicity Biochemistry Biological Sciences Clotting Coagulation Drug Design Enzymes Fluorescence Fluorescence Resonance Energy Transfer Humans Kinetics Ligands Molecular interactions Molecules Partial thromboplastin time Physical Sciences Protein Binding Studies
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