Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus

In the absence of an effective vaccine, there is an urgent need for safe and effective antiviral agents to prevent transmission of HIV. Here, we report that an amphipathic α-helical peptide derived from the hepatitis C virus NS5A anchor domain (designated C5A in this article) that has been shown to...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-04, Vol.105 (14), p.5525-5530
Hauptverfasser:	Bobardt, Michael D, Cheng, Guofeng, de Witte, Lot, Selvarajah, Suganya, Chatterji, Udayan, Sanders-Beer, Brigitte E, Geijtenbeek, Teunis B.H, Chisari, Francis V, Gallay, Philippe A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antivirals Biological Sciences CD4-Positive T-Lymphocytes - virology Cells, Cultured Dendritic cells Dendritic Cells - virology Disease prevention Disease transmission Epithelial cells Hepacivirus - chemistry Hepatitis Hepatitis C Hepatitis C virus Hepatology HIV HIV - drug effects HIV 1 HIV infections HIV Infections - prevention & control Human immunodeficiency virus Humans Infections Liver Macrophages - virology Peptide Fragments - pharmacology Peptide Fragments - therapeutic use T lymphocytes Vaccines Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - pharmacology Viral Nonstructural Proteins - therapeutic use Viruses
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