TGFβ promotes conversion of CD16⁺ peripheral blood NK cells into CD16⁻ NK cells with similarities to decidual NK cells

During pregnancy the uterine decidua is populated by large numbers of natural killer (NK) cells with a phenotype CD56superbrightCD16⁻CD9⁺KIR⁺ distinct from both subsets of peripheral blood NK cells. Culture of highly purified CD16⁺CD9⁻ peripheral blood NK cells in medium containing TGFβ1 resulted in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-02, Vol.104 (9), p.3378-3383
Hauptverfasser:	Keskin, Derin B, Allan, David S.J, Rybalov, Basya, Andzelm, Milena M, Stern, Joel N.H, Kopcow, Hernan D, Koopman, Louise A, Strominger, Jack L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Blood Cultured cells Cytokines Cytometry Endometrium Natural killer cells Phenotypes Progenitor cells Stem cells Stromal cells
Online-Zugang:	Volltext
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