synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy-entropy compensation

The molecular host cucurbit[7]uril forms an extremely stable inclusion complex with the dicationic ferrocene derivative bis(trimethylammoniomethyl)ferrocene in aqueous solution. The equilibrium association constant for this host-guest pair is 3 x 10¹⁵ M⁻¹ (Kd = 3 x 10⁻¹⁶ M), equivalent to that exhib...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-12, Vol.104 (52), p.20737-20742
Hauptverfasser:	Rekharsky, Mikhail V, Mori, Tadashi, Yang, Cheng, Ko, Young Ho, Selvapalam, N, Kim, Hyunuk, Sobransingh, David, Kaifer, Angel E, Liu, Simin, Isaacs, Lyle, Chen, Wei, Moghaddam, Sarvin, Gilson, Michael K, Kim, Kimoon, Inoue, Yoshihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous chemistry Aqueous solutions Avidin - chemistry Binding sites Biological Sciences Biotin - chemistry Biotinylation Bridged-Ring Compounds - chemistry Calorimetry - methods Chemistry - methods Crystal structure Crystallography, X-Ray - methods Enthalpy Entropy Ferrocenes Free energy Hydrogen Bonding Imidazoles - chemistry Kinetics Mathematical minima Models, Molecular Molecular Conformation Molecular Structure Molecules Protons Streptavidin Thermodynamics
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