Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway

The sodium-chloride cotransporter (NCC) is the principal salt-absorptive pathway in the mammalian distal convoluted tubule (DCT) and is the site of action of one of the most effective classes of antihypertensive medications, thiazide diuretics. We developed a cell model system to assess NCC function...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-12, Vol.104 (50), p.20120-20125
Hauptverfasser:	Ko, Benjamin, Joshi, Leena M, Cooke, Leslie L, Vazquez, Norma, Musch, Mark W, Hebert, Steven C, Gamba, Gerardo, Hoover, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption - drug effects Absorption - physiology Animals B lymphocytes Biological Sciences Cells Cells, Cultured Diuretics Effects Gene expression Gene expression regulation Gene silencing Guanine Nucleotide Exchange Factors - metabolism Immunoblotting Kidney Tubules, Distal - drug effects Kidney Tubules, Distal - metabolism Mice Oocytes Physiological regulation Physiology Protein isoforms Protein Kinase C - physiology Proteins Salt Signal Transduction - drug effects Signal Transduction - physiology Small interfering RNA Sodium Chloride Symporter Inhibitors - pharmacology Sodium Chloride Symporters - metabolism Tetradecanoylphorbol Acetate - pharmacology Vehicles Xenopus laevis
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