Chronic stimulation of Nod2 mediates tolerance to bacterial products

The Toll-like receptor (TLR) and nucleotide-binding oligomerization domain (Nod) families of proteins are critical for bacterial recognition, and, acutely, this frequently leads to proinflammatory responses. Polymorphisms in Nod2 (CARD 15) are associated with an increased likelihood of developing Cr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-12, Vol.104 (49), p.19440-19445
Hauptverfasser:	Hedl, Matija, Li, Jing, Cho, Judy H, Abraham, Clara
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - immunology Acetylmuramyl-Alanyl-Isoglutamine - pharmacology Bacteria Binding sites Biological Sciences Cells, Cultured Crohn disease Crohn's disease Cytokines Cytokines - metabolism Down regulation Flora Homeostasis Homozygote Humans Immune Tolerance Interleukin-1 Receptor-Associated Kinases - metabolism Interleukin-1beta - metabolism Intestines - immunology Intestines - microbiology Ligands Lipid A - immunology Lipid A - pharmacology Lipids Macrophages Macrophages - immunology Nod2 Signaling Adaptor Protein - agonists Nod2 Signaling Adaptor Protein - genetics Phagocytosis Polymorphism Pretreatment Secretion Small interfering RNA Toll-Like Receptor 2 - agonists Toll-Like Receptor 4 - agonists Up-Regulation
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